Within the zebrafish project we generated a model for human obesity in Danio rerio (zebrafish). Obesity is an epidemic that affects over 42% of individuals in the United States. Obesity has been linked to the pathogenesis of various diseases including but not limited to non-alcoholic fatty liver disease, type II diabetes, hypertension, etc. Within the scope of this study, we aim to analyze and compare obese and controlled zebrafish livers in terms of their molecular differences and alterations in factors such as epigenetic profiles, disordered proteins, immune regulation, and overall gene expression. Alongside the guidance of Dr. Dobrinski, the zebrafish team have all focused on different biological aspects of this project. Alyssa is tasked with analyzing transcriptome data to investigate differences in gene expression related to immunity between control and obese zebrafish. Jillian is focusing on the effects of obesity on intrinsically disordered proteins and copy number variants as well as metabolism. Hailyn is completing an expression quantitative trait loci (eQTL) analysis where she is monitoring structural variation and transcription of genes upstream, downstream, and overlapping observed variants. Lillian will also be utilizing an eQTL analysis to investigate how copy number variants affect gene expression and what role miRNA plays in overall regulation. Alexandra is studying differential methylation patterns between the obese and control zebrafish and how epigenetic status correlates to changes in overall gene expression. Currently we are in the process of raising more zebrafish to add to our current collection of data and findings. Ultimately, we hope to add to the growing body of knowledge regarding obesity and the subsequent molecular changes related to disease initiation and progression that may occur. We are working towards understanding how this research applies to overall human physiology and the development of obesity associated diseases.